Background:
@EN The aim of this study is to determine the annual occurrence of nosocomial candidemia, the relation between Candida species and underlying illness, the relation bewteen Candida species and predisposing factors, and also to compare between the
outcome
of candidemia of the amphotericin B treatment group and that of the fluconazole treatment group.
@ES Methods:
@EN We reviewed medical records of 61 cases with nosocomial candidemia between 1989 and 1993 in Kyung Hee University Hospital retrospectively.
@ES Results:
@EN Two cases occurred in 1988, 7 in 1990, 11 in 1991, 15 in 1992, and 17 in 1993. The incidence of candidemai by non-albicans species has increased during this period and accounted for 64.7%in 1993. The in fecting candida species were C.
albicans(30
cases, 49.2%), Ctropicalis(13 cases, 21.3%), C. parapsilosis(10 cases, 16.4%), C. glabrata(6 cases, 9.8%), C. grilliermondii(1 cases, 1.8%), and C. krusei(1case, 1.8%). The most common underlying disease was cerebrovascular disease(41%) followed
by
surgical disease(18%), solid cancer(16.4%), hematological malignancies(14.8%), and other medical illness. There were no significant differences between the amphotericin B treatment group(n=20) and the fluconzaole treatment group(n=11) in
mortaiity.
Overall mortality was 45.9%. The highest mortality was in patients with previous orthopaedic surgery(83.3%) and with C. glabrata candidemia(83.3%).
@ES Conclusion:
@EN Candidemia emerged as an important hospital infection and candidemia caused by non-albicans species has significantly increased in recent years.
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